Snapshot caption : The negative molecule changed the shape by having it lean towards the left instead of the upper right like model A.ġ. Snapshot caption : The hydrophilic molecule was pushed to the outside of the clump while the other molecules continued to cluster. Snapshot caption : The molecules clumped together in a cluster. At first in the oil I clustered, then in the water I spread out creating a straight chain. Describe your interactions with the solvent molecules in oil and then in water. Imagine you are one of the amino acids in the hydrophilic chain, first in oil and then in water. Describe your interactions with other amino acids and with water molecules.Īs a hydrophilic amino acid I, along with my fellow buddies, spread out so that we didn't cluster. Imagine you are one of the hydrophilic amino acids. Click on "Hydrophilic amino acids" above, and run the model. What do you experience as the chain folds in water? Describe your interactions with other amino acids and with water molecules.Īs an hydrophobic amino acid I gathered together with the fellow hydrophobic amino acids in a large cluster.Ģ. Run the model, and imagine you are one of the hydrophobic amino acids. THe blue molecules whent they were nonpolar moved around more, causing the purple molecules to not clump together easily.ġ. Once you have gotten the purple hydrophobic molecules to form clumps, set the slider to make the blue molecules non-polar. When the blue molecules were polar they made the purple molecules move around more.Ģ.
What happens to the purple hydrophobic molecules? Why? Set the slider so that the blue molecules act like water molecules, then run the model. The positive and negative molecules coiled around each other due to their charge.ġ. The shape created was a circular cluster. What shape did the protein fold into when the amino acids were half positive and half negative? Explain why it folded that way, describing the interactions of amino acids with each other. THe amino acid came together in a large circular cluster as before, but took a longer time to do so.ġ. Snapshot caption : The majority of the neutral molecules are on the outside of the large cluster. Snapshot caption : The positive and negative molecules wrapped around one another to create a large coiled amino acid. My report on "Protein Folding" My report on "Protein Folding"
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